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Science 7 November 1980:
Vol. 210. no. 4470, pp. 641 - 642
DOI: 10.1126/science.7433989
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Articles

Science, Vol 210, Issue 4470, 641-642
Copyright © 1980 by American Association for the Advancement of Science

articles

Subcellular origin of cholinergic transmitter release from mouse brain

PT Carroll and JM Aspry

Samples of minced mouse forebrain were treated in a way that resulted in a high ratio of false cholinergic transmitter (acetylhomocholine) to true transmitter (acetylcholine) in a synaptic vesicle fraction, and a low ratio of false to true transmitter in the nerve terminal cytoplasm. The spontaneous release of cholinergic transmitters from this minced tissue occurred independently of calcium and had a ratio of false to true transmitter similar to that of the cytoplasm, whereas the evoked transmitter release required calcium and had a ratio of false to true transmitter similar to that of the vesicular fraction.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)