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Science 24 October 1980:
Vol. 210. no. 4468, pp. 441 - 443
DOI: 10.1126/science.6254143
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Articles

Science, Vol 210, Issue 4468, 441-443
Copyright © 1980 by American Association for the Advancement of Science

articles

Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors

TK Harden, CU Cotton, GL Waldo, JK Lutton, and JP Perkins

Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.


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