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Science 24 October 1980:
Vol. 210. no. 4468, pp. 433 - 435
DOI: 10.1126/science.7433983
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Articles

Science, Vol 210, Issue 4468, 433-435
Copyright © 1980 by American Association for the Advancement of Science

articles

Metabolism of propachlor by the germfree rat

JE Bakke, JA Gustafsson, and BE Gustafsson

Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat.
W. Meinl, S. Sczesny, R. Brigelius-Flohe, M. Blaut, and H. Glatt (2009)
Drug Metab. Dispos. 37, 1179-1186
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