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Science 17 October 1980:
Vol. 210. no. 4467, pp. 342 - 343
DOI: 10.1126/science.7423198
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Articles

Science, Vol 210, Issue 4467, 342-343
Copyright © 1980 by American Association for the Advancement of Science

articles

Lithium reduces the number of acetylcholine receptors in skeletal muscle

A Pestronk and DB Drachman

Extended treatment of rats with lithium inhibits the increase in the number of extrajunctional acetylcholine receptors that occurs in their denervated skeletal muscle. In normal muscle, lithium reduces the number of acetylcholine receptors at neuromuscular junctions. These changes appear to be a relatively specific effect of lithium on the turnover of receptors. Skeletal muscle provides an accessible system for analyzing the role of lithium (and other cations) in the regulation of cell surface receptors. This regulation may play a role in the mechanism by which lithium prevents recurrent manic-depressive episodes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myasthenia Gravis Disclosed by Lithium Carbonate.
B. Alevizos, S. Gatzonis, and Ch. Anagnostara (2006)
J Neuropsychiatry Clin Neurosci 18, 427-429
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Drugs and Myasthenia Gravis: An Update.
E. T. Wittbrodt (1997)
Arch Intern Med 157, 399-408
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