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Science 10 October 1980:
Vol. 210. no. 4466, pp. 190 - 193
DOI: 10.1126/science.6997994
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Articles

Science, Vol 210, Issue 4466, 190-193
Copyright © 1980 by American Association for the Advancement of Science

articles

Autoantibodies against axonal neurofilaments in patients with Kuru and Creutzfeldt-Jakob disease

J Sotelo, CJ Gibbs Jr, and DC Gajdusek

The serums of some patients with subacute spongiform encephalopathies contain an autoantibody in higher titer against a normal fibrillar protein within the axon of mature central neurons in culture. The morphological features of this neurofilament, as demonstrated by immunofluorescence and immunoperoxidase staining, and the partial characterization of the antibody are described. The detection of this hetero-specific autoantibody is the first evidence of an immune reaction in the spongiform encephalopathies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autoantibodies to Brain Components and Antibodies to Acinetobacter calcoaceticus Are Present in Bovine Spongiform Encephalopathy.
H. Tiwana, C. Wilson, J. Pirt, W. Cartmell, and A. Ebringer (1999)
Infect. Immun. 67, 6591-6595
   Abstract »    Full Text »    PDF »
Circulating autoantibodies to the 200,000-dalton protein of neurofilaments in the serum of healthy individuals.
K Stefansson, L. Marton, M. Dieperink, G. Molnar, W. Schlaepfer, and C. Helgason (1985)
Science 228, 1117-1119
   Abstract »    PDF »
Supranuclear Gaze Palsy in Familial Creutzfeldt-Jakob Disease.
J. M. Bertoni, L. S. Label, J. C. Sackelleres, and S. P. Hicks (1983)
Arch Neurol 40, 618-622
   Abstract »    PDF »


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