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Science 26 September 1980:
Vol. 209. no. 4464, p. 1541
DOI: 10.1126/science.7433975
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Articles

Science, Vol 209, Issue 4464, 1541-1541
Copyright © 1980 by American Association for the Advancement of Science

articles

Naegleria fowleri: trimethoprim sensitivity

L Cerva

Trimethoprim in a concentration of 4 micrograms per milliter of Bacto-Casitone (Difco) medium inhibits the growth of nonvirulent Naegleria fowleri isolates. The growth of virulent strains is unaffected even with 400 micrograms of the drug per milliliter of medium. Differences in sensitivity constitute the possibility of a simple selection of environmental isolates. The pathogenicity and virulence of Naegleria species may be connected with the metabolism of folic acid.




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