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Science 19 September 1980:
Vol. 209. no. 4463, pp. 1336 - 1342
DOI: 10.1126/science.7414319
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Articles

Science, Vol 209, Issue 4463, 1336-1342
Copyright © 1980 by American Association for the Advancement of Science

articles

Mouse globin system: a functional and evolutionary analysis

P Leder, JN Hansen, D Konkel, A Leder, Y Nishioka, and C Talkington

Structural and functional analysis of the mouse alpha-globin and beta-globin genes reveals that the globin genes are encoded in discontinous bits of coding information and that each gene locus is much more complex than was originally supposed. Each seems to consist of an array of several authentic genes as well as several apparently inactive pseudogenes. Comparison of the sequences of some of these genes to one another indicates that chromosomal DNA is a dynamic structure. Flanking and intervening sequences change in two ways: quickly, by duplication and extensive insertions and deletions, and slowly, by point mutation. Active coding sequences are usually limited to the slower mode of evolution. In addition to identifying fast and slow modes of evolution, it has also been possible to test the function of several signals that surround these genes and to identify those that appear to play a role in gene expression.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice.
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Genetics 177, 481-500
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Comparative Analysis of the {alpha}-Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates a Mechanism Underlying Breaks in Conserved Synteny.
C. Tufarelli, R. Hardison, W. Miller, J. Hughes, K. Clark, N. Ventress, A. M. Frischauf, and D. R. Higgs (2004)
Genome Res. 14, 623-630
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Oxygen tension modulates ß-globin switching in embryoid bodies.
S. BICHET, R. H. WENGER, G. CAMENISCH, A. ROLFS, W. EHLEBEN, T. PORWOL, H. ACKER, J. FANDREY, C. BAUER, and M. GASSMANN (1999)
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An in vitro globin gene switching model based on differentiated embryonic stem cells..
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The mosaic genome of warm-blooded vertebrates.
G Bernardi, B Olofsson, J Filipski, M Zerial, J Salinas, G Cuny, M Meunier-Rotival, and F Rodier (1985)
Science 228, 953-958
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Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome.
E. Reddy, M. Smith, and S. Aaronson (1981)
Science 214, 445-450
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