Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 September 1980:
Vol. 209. no. 4462, pp. 1259 - 1261
DOI: 10.1126/science.6250222
Prev | Table of Contents | Next

Articles

Science, Vol 209, Issue 4462, 1259-1261
Copyright © 1980 by American Association for the Advancement of Science

articles

Stress-induced eating is mediated through endogenous opiates

JE Morley and AS Levine

The interaction of endogenous opiates and stress-induced eating in rats was evaluated by pharmacological manipulation. Eating induced by the tail-pinch method was inhibited by the opitate antagonist naloxone; after being repeatedly stressed over a 10-day period and then given nalozone, the rats behaved in a manner indistinguishable from the "wet-dog" shakes of opiate withdrawal. Thus endogenous opiates may have a role in the control of stress-related eating, a finding that may have therapeutic implications for humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Galanin-Like Peptide Stimulates Food Intake via Activation of Neuropeptide Y Neurons in the Hypothalamic Dorsomedial Nucleus of the Rat.
M. Kuramochi, T. Onaka, D. Kohno, S. Kato, and T. Yada (2006)
Endocrinology 147, 1744-1752
   Abstract »    Full Text »    PDF »
Sucrose consumption increases naloxone-induced c-Fos immunoreactivity in limbic forebrain.
J. D. Pomonis, D. C. Jewett, C. M. Kotz, J. E. Briggs, C. J. Billington, and A. S. Levine (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R712-R719
   Abstract »    Full Text »    PDF »
Neuropeptide Y Attenuates Naloxone-Precipitated Morphine Withdrawal via Y5-like Receptors.
D. P. D. Woldbye, K. Klemp, and T. M. Madsen (1998)
J. Pharmacol. Exp. Ther. 284, 633-636
   Abstract »    Full Text »
Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin.
P. Faris, C. McLaughlin, C. Baile, J. Olney, and B. Komisaruk (1984)
Science 226, 1215-1217
   Abstract »    PDF »
High-Dose Naloxone Infusions in Normals: Dose-Dependent Behavioral, Hormonal, and Physiological Responses.
M. R. Cohen, R. M. Cohen, D. Pickar, H. Weingartner, and D. L. Murphy (1983)
Arch Gen Psychiatry 40, 613-619
   Abstract »    PDF »
Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia.
P. Faris, B. Komisaruk, L. Watkins, and D. Mayer (1983)
Science 219, 310-312
   Abstract »    PDF »
Endogenous opiates and stress-induced eating.
S. Antelman and N Rowland (1981)
Science 214, 1149-1151
   PDF »
Endogenous Opiates and Stress-Induced Eating.
J. E. MORLEY and A. S. LEVINE (1981)
Science 214, 1150-1151
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)