Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 September 1980:
Vol. 209. no. 4462, pp. 1247 - 1249
DOI: 10.1126/science.6250221
Prev | Table of Contents | Next

Articles

Science, Vol 209, Issue 4462, 1247-1249
Copyright © 1980 by American Association for the Advancement of Science

articles

1 alpha, 25-Dihydroxyvitamin D3 nuclear receptors in pituitary

HA Gelbard, PH Stern, and DC U'Prichard

Specific binding of 1 alpha,25-dihydroxyvitamin D(3) was found in nuclear and cytosol fractions of the bovine pituitary. For nuclear binding. the dissociation constant was 0.1 namomole per liter, and maximum binding was 104 femtomoles per milligram of protein. In competition studies, 25-hydroxyvitamin D(3) was 300 times weaker than 1 alpha,25-dihydroxyvitamin D(3). The existence of high-affinity sites supports a physiologic role for 1 alpha,25-dihydroxyvitamin D(3) in the pituitary.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Can Vitamin D Deficiency Produce an Unusual Pain Syndrome?.
F. M. Gloth III, J. M. Lindsay, L. B. Zelesnick, and W. B. Greenough III (1991)
Arch Intern Med 151, 1662-1664
   Abstract »    PDF »
Brain target sites for 1,25-dihydroxyvitamin D3.
W. Stumpf, M Sar, S. Clark, and H. DeLuca (1982)
Science 215, 1403-1405
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)