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Science 5 September 1980:
Vol. 209. no. 4461, pp. 1134 - 1136
DOI: 10.1126/science.7403873
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Articles

Science, Vol 209, Issue 4461, 1134-1136
Copyright © 1980 by American Association for the Advancement of Science

articles

Flavin adenine dinucleotide--dependent monooxygenase: its role in the sulfoxidation of pesticides in mammals

NP Hajjar and E Hodgson

The flavin adenine dinucleotide--dependent monooxygenase in mammalian hepatic microsomes plays a major role in the oxidative metabolism of thioether-containing pesticides. Thirty-four compounds were tested, and it was determined that organophosphorus insecticides such as disulfoton and phorate are rapidly oxidized by the purified enzyme to their corresponding sulfoxides. The enzyme does not catalyze the oxidation of the thiophosphoryl and thiol sulfur atoms of these or other phosphorothioates and phosphorodithioates, or the oxidation of the sulfoxide to the sulfone. Carbamates aldicarb and Croneton are also oxidized, but at a lower rate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
EXTRAHEPATIC METABOLISM OF CARBAMATE AND ORGANOPHOSPHATE THIOETHER COMPOUNDS BY THE FLAVIN-CONTAINING MONOOXYGENASE AND CYTOCHROME P450 SYSTEMS.
B. Furnes and D. Schlenk (2005)
Drug Metab. Dispos. 33, 214-218
   Abstract »    Full Text »    PDF »
Evaluation of Xenobiotic N- and S-Oxidation by Variant Flavin-Containing Monooxygenase 1 (FMO1) Enzymes.
B. Furnes and D. Schlenk (2004)
Toxicol. Sci. 78, 196-203
   Abstract »    Full Text »    PDF »
IN VITRO SULFOXIDATION OF THIOETHER COMPOUNDS BY HUMAN CYTOCHROME P450 AND FLAVIN-CONTAINING MONOOXYGENASE ISOFORMS WITH PARTICULAR REFERENCE TO THE CYP2C SUBFAMILY.
K. A. Usmani, E. D. Karoly, E. Hodgson, and R. L. Rose (2004)
Drug Metab. Dispos. 32, 333-339
   Abstract »    Full Text »    PDF »
Identification of Novel Variants of the Flavin-Containing Monooxygenase Gene Family in African Americans.
B. Furnes, J. Feng, S. S. Sommer, and D. Schlenk (2003)
Drug Metab. Dispos. 31, 187-193
   Abstract »    Full Text »    PDF »
Effects of Salinity on Aldicarb Toxicity in Juvenile Rainbow Trout (Oncorhynchus mykiss) and Striped Bass (Morone saxatilisxchrysops).
J. Wang, S. Grisle, and D. Schlenk (2001)
Toxicol. Sci. 64, 200-207
   Abstract »    Full Text »    PDF »


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