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Science 29 August 1980:
Vol. 209. no. 4460, pp. 1032 - 1034
DOI: 10.1126/science.6157190
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Articles

Science, Vol 209, Issue 4460, 1032-1034
Copyright © 1980 by American Association for the Advancement of Science

articles

Prostaglandin A compounds as antiviral agents

MG Santoro, A Benedetto, G Carruba, E Garaci, and BM Jaffe

Prostaglandins of the A series strongly inhibit the production of Sendai virus in African green monkey kidney cells and are able to prevent the establishment of persistent infection ("carrier" state). This action is specific for prostaglandin A and is not due to alteration in the host cell metabolism or in the virus infectivity. The possibility that this effect is mediated by interferon is discussed.


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