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Science 15 August 1980:
Vol. 209. no. 4458, pp. 817 - 819
DOI: 10.1126/science.7403848
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Articles

Science, Vol 209, Issue 4458, 817-819
Copyright © 1980 by American Association for the Advancement of Science

articles

Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride

W Lijinsky, MD Reuber, and BN Blackwell

The antihistaminic over-the-counter drug methapyrilene hydrochloride, mixed with food at a concentration of 0.1 percent, was administered to 50 male and 50 female Fischer rats. A second group of 50 male and 50 female rats was given the same treatment together with 0.2 percent of sodium nitrite added to the food. Almost all of the rats in both groups developed liver neoplasms, mainly hepatocellular carcinomas and cholangiocarcinomas. The first rat died with a liver neoplasm at the 43rd week. Over 50 percent of the rats in both groups had metastases from the carcinomas of the liver to distant organs. Control rats treated with nitrite only, or untreated, did not develop liver neoplasms. There was no discernible effect of nitrite on the carcinogenicity of methapyrilene hydrochloride.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Methapyrilene Toxicity: Anchorage of Pathologic Observations to Gene Expression Alterations.
H. K. Hamadeh, B. L. Knight, A. C. Haugen, S. Sieber, R. P. Amin, P. R. Bushel, R. Stoll, K. Blanchard, S. Jayadev, R. W. Tennant, et al. (2002)
Toxicol Pathol 30, 470-482
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Proceedings of the British Toxicology Society Annual Congress University of Surrey, Guildford 19 - 22 April 1998.
(1998)
Human and Experimental Toxicology 17, 469-534
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Safety Assessment of Pharmaceuticals: Examples of Inadequate Assessments and a Mechanistic Approach to Assuring Adequate Assessment.
G. M. Williams (1997)
Toxicol Pathol 25, 32-38
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Chronic Toxicity/Carcinogenicity Study of Pyrilamine in B6C3F1 Mice.
D. L. Greenman, R. Allen, R. Dahlgren, G. M. Cronin, and W. T. Allaben (1995)
International Journal of Toxicology 14, 148-157
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Subchronic Studies of Pyrilamine in Fischer 344 Rats.
D. L. Greenman, R. Morrissey, D. W. Gaylor, and W. T. Allaben (1993)
International Journal of Toxicology 12, 175-183
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2-year Toxicity Study of Doxylamine Succinate in the Fischer 344 Rat.
C. D. Jackson and B.-N. Blackwell (1993)
International Journal of Toxicology 12, 1-11
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Subchronic Studies of Tripelennamine in Fischer 344 Rats.
C. D. Jackson and B.-N. Blackwell (1991)
International Journal of Toxicology 10, 493-502
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Subchronic Studies of Tripelennamine in B6C3F1 Mice.
C. D. Jackson and B.-N. Blackwell (1991)
International Journal of Toxicology 10, 503-510
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Subchronic Studies of Thenyldiamine in B6C3F1 Mice.
C. D. Jackson, G. M. Cronin, and T. W. Stone (1991)
International Journal of Toxicology 10, 243-253
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Subchronic Studies of Thenyldiamine in Fischer 344 Rats.
C. D. Jackson, G. M. Cronin, and T. W. Stone (1990)
International Journal of Toxicology 9, 61-70
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Free Radical Injury and Liver Tumor Promotion.
M. I. R. Perera, J. M. Betschart, M. A. Virji, S. L. Katyal, and H. Shinozuka (1987)
Toxicol Pathol 15, 51-59
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