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Science 15 August 1980:
Vol. 209. no. 4458, pp. 811 - 813
DOI: 10.1126/science.6250215
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Articles

Science, Vol 209, Issue 4458, 811-813
Copyright © 1980 by American Association for the Advancement of Science

articles

Thyroid hormone receptor-containing fragment released from chromatin by deoxyribonuclease I and micrococcal nuclease

DB Jump and JH Oppenheimer

Limited deoxyribonuclease I and micrococcal nuclease digestion of hepatic nuclei from euthyroid rats injected with 125I-labeled triiodothyronine ([125I]T3) releases a discrete [125I]T3-labeled chromatin fragment (5.8S) which is larger than the T3 receptor (3.5S). These results suggest the T3 receptor is associated with a restricted fraction of hepatic chromatin that has a nuclease sensitivity characteristic of transcriptionally active chromatin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thyroid Hormone Action at the Nuclear Level.
J. H. OPPENHEIMER (1985)
Ann Intern Med 102, 374-384
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