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Science 15 August 1980:
Vol. 209. no. 4458, pp. 768 - 776
DOI: 10.1126/science.6250214
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Articles

Science, Vol 209, Issue 4458, 768-776
Copyright © 1980 by American Association for the Advancement of Science

articles

Teratocarcinomas and mammalian embryogenesis

GR Martin

In the last decade there has emerged an appreciation of the remarkable similarity between the cells that give rise to teratocarcinomas in mice and the cells that give rise to the developing mouse embryo. The resemblance is so close that in certain instances the tumor stem cells can join with their embryonic counterparts and develop into a completely normal mouse. The availability of stem cell lines isolated from mouse teratocarcinomas has made possible a number of new biochemical, immunological, and genetic approahes to the study of early mammalian development.


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