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Science 8 August 1980:
Vol. 209. no. 4457, pp. 708 - 710
DOI: 10.1126/science.7394531
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Articles

Science, Vol 209, Issue 4457, 708-710
Copyright © 1980 by American Association for the Advancement of Science

articles

Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex

JN Nestoros

Ethanol (ethyl alcohol) potentiates the inhibition of cortical neurons by gamma-aminobutyric acid. This effect is specific, since ethanol does not potentiate inhibiton by glycine, serotonin, or dopamine. These results have implications for alcoholism because (i) gamma-aminobutyric acid mediates anxiolytic mechanisms, and (ii) anxiety is implicated in the etiology of alcoholism.


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{gamma}-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment..
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Ethanol Dual Modulatory Actions on Spontaneous Postsynaptic Currents in Spinal Motoneurons.
L. Ziskind-Conhaim, B.-X. Gao, and C. Hinckley (2003)
J Neurophysiol 89, 806-813
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Chronic Exposure to Ethanol Alters GABAA Receptor-Mediated Responses of Layer II Pyramidal Cells in Adult Rat Piriform Cortex.
A. P. Signore and H. H. Yeh (2000)
J Neurophysiol 84, 247-254
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Interactive Role for Neurosteroids in Ethanol Enhancement of gamma -Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons.
H. E. Criswell, T. J. McCown, Z. Ming, R. A. Mueller, and G. R. Breese (1999)
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Beta Adrenergic Sensitization of gamma -Aminobutyric Acid Receptors to Ethanol Involves a Cyclic AMP/Protein Kinase A Second-Messenger Mechanism.
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The Effects of Alcohol Consumption on Laboratory-Induced Panic and State Anxiety.
M. G. Kushner, T. B. Mackenzie, J. Fiszdon, D. P. Valentiner, E. Foa, N. Anderson, and D. Wangensteen (1996)
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Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes.
K. Wafford, D. Burnett, T. Dunwiddie, and R. Harris (1990)
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Ethanol inhibits NMDA-activated ion current in hippocampal neurons.
D. Lovinger, G White, and F. Weight (1989)
Science 243, 1721-1724
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Cellular and molecular mechanisms of drug dependence.
G. Koob and F. Bloom (1988)
Science 242, 715-723
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Pharmacologic Probe With Progabide of GABA Mechanisms in Essential Tremor.
W. C. Koller, F. Rubino, and S. Gupta (1987)
Arch Neurol 44, 905-906
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The emerging pharmacology of ethanol.
F. E. Bloom (1987)
J Psychopharmacol 1, 227-236
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A selective imidazobenzodiazepine antagonist of ethanol in the rat.
P. Suzdak, Glowa JR, J. Crawley, R. Schwartz, P Skolnick, and S. Paul (1986)
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Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus.
J. Mancillas, G. Siggins, and F. Bloom (1986)
Science 231, 161-163
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Ethanol in low doses augments calcium-mediated mechanisms measured intracellularly in hippocampal neurons.
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