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Science 1 August 1980:
Vol. 209. no. 4456, pp. 611 - 612
DOI: 10.1126/science.6994228
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Articles

Science, Vol 209, Issue 4456, 611-612
Copyright © 1980 by American Association for the Advancement of Science

articles

Vascular permeation of platelet factor 4 after endothelial injury

ID Goldberg, MB Stemerman, and RI Handin

Antibody to platelet factor 4 was used to demonstrate permeation of this factor into the blood vessel wall after endothelial injury in rabbits. The presence of platelet factor 4 antigen in the vessel wall after removal of the endothelium was shown by immunofluorescence 10 and 30 minutes after injury but not 240 minutes afterward. This study demonstrates that factors carried by platelets can enter the vessel wall and that the movement of these platelet products into the vasculature is a short-lived, self-limiting process.


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