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Science 25 July 1980:
Vol. 209. no. 4455, pp. 520 - 521
DOI: 10.1126/science.6967228
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Articles

Science, Vol 209, Issue 4455, 520-521
Copyright © 1980 by American Association for the Advancement of Science

articles

Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5

C Terhorst, A van Agthoven, E Reinherz, and S Schlossman

Two major functionally distinct T cell subsets in man have been defined with heteroantiserums and monoclonal antibodies directed against stable cell surface antigens that appear during thymic ontogeny. A monoclonal antibody to T4 antigen (anti-T4) is reactive with the peripheral inducer T cell population while a monoclonal antibody to T5 antigen (anti-T5) is reactive with the cytotoxic and suppressor population. Immunoprecipitation and electrophoresis on sodium dodecyl sulfate polyacrylamide gel were used to show that on human thymocytes or peripheral T cells the T4 antigen is a single 62,000-dalton glycoprotein while the T5 antigen is a complex of two glycoproteins, one being 30,000 daltons and the other 32,000 daltons. Similar glycoproteins have been isolated with antibodies to murine Lyt 1 and Lyt 2,3 antigens. Both the antigens defining the phenotypes of inducer and suppressor populations in man and mouse are structurally homologous.


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