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Science 25 July 1980:
Vol. 209. no. 4455, pp. 517 - 519
DOI: 10.1126/science.6967227
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Articles

Science, Vol 209, Issue 4455, 517-519
Copyright © 1980 by American Association for the Advancement of Science

articles

Developmental potential of somatic nuclei transplanted into meiotic oocytes of Rana pipiens

NJ Hoffner and MA DiBerardino

Somatic nuclei, when transplanted into oocytes at the stage of first meiotic metaphase, were induced to undergo chromosome condensation and alignment on spindles. When the oocytes completed maturity in vitro and were activated, the somatic nuclei transformed into "fertilization" nuclei and promoted development through embryogenesis. Thus somatic nuclei can reversibly respond to cytoplasms directing either meiotic or mitotic events, and somatic nuclei from differentiated cells may be reversed by conditioning in oocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation of dormant genes in specialized cells.
M. DiBerardino, N. Hoffner, and L. Etkin (1984)
Science 224, 946-952
   Abstract »    PDF »
Gene reactivation in erythrocytes: nuclear transplantation in oocytes and eggs of Rana.
M. DiBerardino and N. Hoffner (1983)
Science 219, 862-864
   Abstract »    PDF »


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