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Science 18 July 1980:
Vol. 209. no. 4454, pp. 388 - 391
DOI: 10.1126/science.7384810
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Articles

Science, Vol 209, Issue 4454, 388-391
Copyright © 1980 by American Association for the Advancement of Science

articles

Evolution of the hemoglobin S and C genes in world populations

YW Kan and AM Dozy

A polymorphic HpaI endonuclease recognition site on the 3' side of the beta-globin gene was used to analyze the evolution of the beta-globin gene mutants S and C. Study of the world wide distribution of the normal and variant HpaI sites showed that the mutation which resulted in the variant 13.0-kilobase fragment arose in a localized region in West Africa. It predated the hemoglobin S and C mutations, both of which arose separately from a chromosome with the variant 13.0-kilobase HpaI site. In contrast, the sickle genes in other parts of Africa and in Asia are associated with the normal 7.6-kilobase HpaI fragment, indicating that the sickle mutations in these other areas arose separately from that in West Africa.


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