Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 June 1980:
Vol. 208. no. 4451, pp. 1469 - 1471
DOI: 10.1126/science.7384789
Prev | Table of Contents | Next

Articles

Science, Vol 208, Issue 4451, 1469-1471
Copyright © 1980 by American Association for the Advancement of Science

articles

Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines

IJ Fidler

Mice of two different strains were injected subcutaneously with spontaneously metastasizing syngeneic melanomas. After 4 to 6 weeks, the local tumors were removed and, 3 days after surgery, treatment of the metastases was initiated. The treatment consisted of intravenous injections of liposomes containing lymphokines or control supernatant fluids. Liposomes were injected twice weekly for 3 weeks, and the mice were killed 2 weeks later. Seventy-three percent of the mice injected with liposomes containing lymphokines were free of metastases, whereas only 10 percent of the mice treated with control liposomes were tumor-free. These experiments suggest that this form of therapy may provide a valuable addition to the more conventional approaches to the eradication of cancer metastases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Models for Spontaneous Metastasis.
I. J. Fidler (2006)
Cancer Res. 66, 9787
   Full Text »    PDF »
Liposomal Applications to Cancer Therapy.
Y. Namba and N. Oku (1993)
Journal of Bioactive and Compatible Polymers 8, 158-177
   PDF »
Human monocytes activated by immunomodulators in liposomes lyse herpesvirus-infected but not normal cells.
W. Koff, I. Fidler, S. Showalter, M. Chakrabarty, B Hampar, L. Ceccorulli, and E. Kleinerman (1984)
Science 224, 1007-1009
   Abstract »    PDF »
Evidence for the clonal origin of spontaneous metastases.
J. Talmadge, Wolman SR, and I. Fidler (1982)
Science 217, 361-363
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)