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Science 27 June 1980:
Vol. 208. no. 4451, pp. 1464 - 1465
DOI: 10.1126/science.6247762
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Articles

Science, Vol 208, Issue 4451, 1464-1465
Copyright © 1980 by American Association for the Advancement of Science

articles

Efficient metal-ion catalyzed template-directed oligonucleotide synthesis

R Lohrmann, PK Bridson, and LE Orgel

The Pb2+ and Zn2+ ions are efficient catalysts for the polycytidylic acid-directed polymerization of an activated guanylic acid derivative, guanosine 5'-phosphorimidazolide. The products include oligomers of 30 to 40 units in length. The nucleotide residues are predominantly 2'-5' linked when Pb2+ is the catalyst, and predominantly 3'-5' linked in the presence of Zn2+. The significance of these results in the context of the prebiotic evolution of RNA polymerase is discussed.


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W. E. Draper, E. J. Hayden, and N. Lehman (2008)
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Montmorillonite-catalysed formation of RNA oligomers: the possible role of catalysis in the origins of life.
J. P Ferris (2006)
Phil Trans R Soc B 361, 1777-1786
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Catalysis and Prebiotic Synthesis.
J. P. Ferris (2005)
Reviews in Mineralogy and Geochemistry 59, 187-210
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In Search of RNA Ancestors.
A.W. Schwartz, J. Visscher, R. Van der Woerd, and C.G. Barker (1987)
Cold Spring Harb Symp Quant Biol 52, 37-39
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