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Science 27 June 1980:
Vol. 208. no. 4451, pp. 1459 - 1461
DOI: 10.1126/science.7384787
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Articles

Science, Vol 208, Issue 4451, 1459-1461
Copyright © 1980 by American Association for the Advancement of Science

articles

An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin

RV Lewis, AS Stern, S Kimura, J Rossier, S Stein, and S Udenfriend

A protein that may be an enkephalin precursor has been identified in extracts of bovine adrenal medulla. This protein (about 50,000 daltons) appears to contain seven copies of [Met]enkephalin and one copy of [Leu]enkephalin. Digestion with trypsin and carboxypeptidase B yields [Met]enkephalin and [Leu]enkephalin in a ratio of almost 7 to 1. The enkephalins were identified by chromatography and by their binding to opiate receptors. Some characteristics of several other adrenal peptides that may serve as intermediates in the biosynthesis of the enkephalins are presented.


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