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Science 16 May 1980:
Vol. 208. no. 4445, pp. 751 - 753
DOI: 10.1126/science.7189297
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Articles

Science, Vol 208, Issue 4445, 751-753
Copyright © 1980 by American Association for the Advancement of Science

articles

Impaired brain growth in neonatal rats exposed to ethanol

J Diaz and HH Samson

Infant rat pups, fed through intragastric cannulas from postnatal day 4 through day 18, showed a 19 percent reduction in total brain weight when ethanol was included in their diet on days 4 through 7. This reduction in brain weight occurred even though body growth in the experimental rats was equal to that of their littermate controls. The ethanol-exposed animals were markedly hypoactive during the period of drug administration, then displayed gross body tremors for 3 to 5 days. Throughout the study, the animals treated with ethanol had poor motor coordination and were hyperresponsive. These brain and behavioral effects appear similar to those seen in fetal alcohol syndrome.


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