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Science 9 May 1980:
Vol. 208. no. 4444, pp. 612 - 615
DOI: 10.1126/science.6245449
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Articles

Science, Vol 208, Issue 4444, 612-615
Copyright © 1980 by American Association for the Advancement of Science

articles

Single-shot channel activation accounts for duration of inhibitory postsynaptic potentials in a central neuron

DS Faber and H Korn

In the goldfish Mauthner cell, inhibitory postsynaptic currents evoked by intracellular stimulation of presynaptic neurons decay exponentially, with a mean time constant of 6.65 milliseconds. Analysis of membrane conductance fluctuations induced by iontophoresis of glycine and gamma-aminobutyric acid indicates a mean inhibitory channel lifetime of 7.15 milliseconds. The results thus suggest that the relaxation kinetics of activated inhibitory channels are rate-limiting during decay of the inhibitory postsynaptic current.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of Glycinergic Synaptic Transmission to Rat Brain Stem Motoneurons.
J. H. Singer, E. M. Talley, D. A. Bayliss, and A. J. Berger (1998)
J Neurophysiol 80, 2608-2620
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Intrinsic quantal variability due to stochastic properties of receptor-transmitter interactions.
D. Faber, W. Young, P Legendre, and H Korn (1992)
Science 258, 1494-1498
   Abstract »    PDF »


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