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Science 2 May 1980:
Vol. 208. no. 4443, pp. 516 - 518
DOI: 10.1126/science.6154315
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Articles

Science, Vol 208, Issue 4443, 516-518
Copyright © 1980 by American Association for the Advancement of Science

articles

Inhibition of cell motility by interferon

D Brouty-Boye and BR Zetter

Interferon derived from human leukocytes, human fibroblasts, and mouse fibroblasts was found to inhibit the motility of cultured cells. It inhibits the tumor-induced motility of capillary endothelial cells as well as the spontaneous migration of other cell types. The ability of a given preparation of interferon to inhibit the motility of a given cell type is proportional to its antiviral activity in that particular cell type. Antiserum to human leukocyte interferon neutralizes both the motility-inhibitory activity and the antiviral activity of this preparation.


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