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Science 2 May 1980:
Vol. 208. no. 4443, pp. 510 - 511
DOI: 10.1126/science.7367875
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Articles

Science, Vol 208, Issue 4443, 510-511
Copyright © 1980 by American Association for the Advancement of Science

articles

DNA polymerases in parasitic protozoans differ from host enzymes

LM Chang, E Cheriathundam, EM Mahoney, and A Cerami

Analysis of extracts of the bloodstream forms of Trypanosoma brucei showed that both DNA polymerase-alpha and DNA polymerase-beta activities were present. The detection of DNA polymerase-beta in T. brucei demonstrates the presence of this enzyme in unicellular organisms. DNA polymerase-beta is present also in Leishmania mexicana. The DNA polymerases in T. brucei are immunologically distinct from the host enzymes. The structural differences between the parasite and the host enzymes could be exploited for the development of agents to combat parasitic diseases.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)