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Science 25 April 1980:
Vol. 208. no. 4442, pp. 406 - 408
DOI: 10.1126/science.7367867
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Articles

Science, Vol 208, Issue 4442, 406-408
Copyright © 1980 by American Association for the Advancement of Science

articles

Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus

MC King, RC Go, RC Elston, HT Lynch, and NL Petrakis

The patterns of the occurrence of breast cancer in 11 high-risk families were evaluated by segregation and linkage analysis. These patterns were consistent with the hypothesis that increased susceptibility to breast cancer was inherited as an autosomal dominant allele with high penetrance in women. The postulated susceptibility allele in these families may be chromosomally linked to the glutamate-pyruvate transaminase (E.C. 2.6.1.2, alanine aminotransferase) locus. Confirmation of this linkage in other families would establish the existence of a gene increasing susceptibility to breast cancer. Since there is no association in the general population between a woman's glutamate-pyruvate transaminase genotype and her cancer risk, the glutamate-pyruvate transaminase linkage cannot be used as a screening test for breast cancer.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Linkage of early-onset familial breast cancer to chromosome 17q21.
J. Hall, M. Lee, B Newman, J. Morrow, L. Anderson, B Huey, and M. King (1990)
Science 250, 1684-1689
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Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.
S Pathak, L. Strong, R. Ferrell, and A Trindade (1982)
Science 217, 939-941
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