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Science 18 April 1980:
Vol. 208. no. 4441, pp. 309 - 311
DOI: 10.1126/science.6892734
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Articles

Science, Vol 208, Issue 4441, 309-311
Copyright © 1980 by American Association for the Advancement of Science

articles

Hepatocarcinogenicity of glandless cottonseeds and cottonseed oil to rainbow trout (Salmo gairdnerii)

JD Hendricks, RO Sinnhuber, PM Loveland, NE Pawlowski, and JE Nixon

Glandless cottonseed kernels are available for purchase and consumption by the general public. These kernels contain no gossypol but still have a full complement of naturally occurring cyclopropenoid fatty acids, which in rainbow trout are active as synergists with aflatoxins and primary liver carcinogens. Diets containing glandless cottonseed kernels or a lightly processes cottonseed oil produced significant numbers of hepatocellular carcinomas in rainbow trout after 1 year. The much greater incidence of cancer induced by the kernel than by the oil indicates that synergists or other carcinogens may be present in the kernel in addition to the cyclopropenoid fatty acids.


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