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Science 18 April 1980:
Vol. 208. no. 4441, pp. 307 - 309
DOI: 10.1126/science.7367861
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Articles

Science, Vol 208, Issue 4441, 307-309
Copyright © 1980 by American Association for the Advancement of Science

articles

Cadmium increases tissue factor (coagulation factor III) activity by facilitating its reassociation with lipids

SD Carson and WH Konigsberg

The coagulant activity of partially purified and delipidated tissue factor (TF) (coagulation Factor III) has previously been recovered by dialysis of the apoprotein after addition of mixed brain lipids and deoxycholate. Inclusion of cadmium chloride in the relipidation mixture greatly increases the recovered activity of highly purified TF from human placenta by promoting incorporation of TF into phospholipid vesicles; TF that had not been incorporated into vesicles showed no coagulant activity. Thus, TF must be present in a lipid bilayer for expression of coagulant activity. In vitro, cadmium induces fusion of lipid vesicles and may contribute to the incorporation of proteins in membranes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protein Hydration during Generation of Coagulation Factor Xa in Aqueous Phase and on Phospholipid Membranes.
M. P. McGee and H. Teuschler (1995)
J. Biol. Chem. 270, 15170-15174
   Abstract »    Full Text »    PDF »
Tissue factor gene localized to human chromosome 1 (1pter----1p21).
S. Carson, W. Henry, and T. Shows (1985)
Science 229, 991-993
   Abstract »    PDF »


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