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Science 11 April 1980:
Vol. 208. no. 4440, pp. 200 - 202
DOI: 10.1126/science.7361118
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Articles

Science, Vol 208, Issue 4440, 200-202
Copyright © 1980 by American Association for the Advancement of Science

articles

Faster cholinergic REM sleep induction in euthymic patients with primary affective illness

N Sitaram, JI Nurnberger Jr, ES Gershon, and JC Gillin

Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex. These results, and others, suggest that patients with primary affective illness may have a supersensitive cholinergic system both when they are ill and when their symptoms are in clinical remission.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Brain Glucose Metabolism During Non--Rapid Eye Movement Sleep in Major Depression: A Positron Emission Tomography Study.
A. P. Ho, J. C. Gillin, M. S. Buchsbaum, J. C. Wu, L. Abel, and W. E. Bunney Jr (1996)
Arch Gen Psychiatry 53, 645-652
   Abstract »    PDF »
Reduced Clonidine Rapid Eye Movement Sleep Suppression in Patients With Primary Major Affective Illness.
M. Schittecatte, G. Charles, R. Machowski, J. Garcia-Valentin, J. Mendlewicz, and J. Wilmotte (1992)
Arch Gen Psychiatry 49, 637-642
   Abstract »    PDF »
The Cholinergic Rapid Eye Movement Induction Test With Arecoline in Depression.
J. C. Gillin, L. Sutton, C. Ruiz, J. Kelsoe, R. M. Dupont, D. Darko, S. C. Risch, S. Golshan, and D. Janowsky (1991)
Arch Gen Psychiatry 48, 264-270
   Abstract »    PDF »
The Cholinergic Rapid Eye Movement Sleep Induction Test With RS-86: State or Trait Marker of Depression?.
M. Berger, D. Riemann, D. Hochli, and R. Spiegel (1989)
Arch Gen Psychiatry 46, 421-428
   Abstract »    PDF »
Multiple-Dose Arecoline Infusions in Alzheimer's Disease.
P. N. Tariot, R. M. Cohen, J. A. Welkowitz, T. Sunderland, P. A. Newhouse, D. L. Murphy, and H. Weingartner (1988)
Arch Gen Psychiatry 45, 901-905
   Abstract »    PDF »
The Effects of Acute Scopolamine in Geriatric Depression.
P. A. Newhouse, T. Sunderland, P. N. Tariot, H. Weingartner, K. Thompson, A. M. Mellow, R. M. Cohen, and D. L. Murphy (1988)
Arch Gen Psychiatry 45, 906-912
   Abstract »    PDF »
Rapid Eye Movement Sleep Characteristics During and After Mood-Disturbing Events.
R. D. Cartwright (1983)
Arch Gen Psychiatry 40, 197-201
   Abstract »    PDF »


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