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Science 11 April 1980:
Vol. 208. no. 4440, pp. 194 - 196
DOI: 10.1126/science.6987737
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Articles

Science, Vol 208, Issue 4440, 194-196
Copyright © 1980 by American Association for the Advancement of Science

articles

Vertebrate cells express protozoan antigen after hybridization

MS Crane and JA Dvorak

Epimastigotes, the invertebrate host stage of Trypanosoma cruzi, the protozoan parasite causing Chagas' disease in man, were fused with vertebrate cells by using polyethylene glycol. Hybrid cells were selected on the basis of T. cruzi DNA complementation of biochemical deficiencies in the vertebrate cells. Some clones of the hybrid cells expressed T. cruzi-specific antigen. It might be possible to use selected antigens obtained from the hybrids as vaccines for immunodiagnosis or for elucidation of the pathogenesis of Chagas' disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Somatic cell hybrids from frog lymphocytes and mouse myeloma cells.
H Hengartner and L Du Pasquier (1981)
Science 212, 1034-1035
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