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Science 11 April 1980:
Vol. 208. no. 4440, pp. 191 - 193
DOI: 10.1126/science.6244621

Articles

Science, Vol 208, Issue 4440, 191-193
Copyright © 1980 by American Association for the Advancement of Science


articles

Phorbol ester action is independent of viral and cellular src kinase levels

AR Goldberg, KB Delclos, and PM Blumberg

Treatment of normal chick embryo fibroblasts with phorbol myristate acetate causes those cells to express many of the phenotypic properties of virally transformed cells and also enhances the expression of transformed properties in Rous sarcoma virus-transformed chick embryo fibroblasts. We report here that phorbol myristate acetate has little or no effect on the level of protein kinases encoded by the viral src or endogenous sarc genes.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)