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Science 11 April 1980:
Vol. 208. no. 4440, pp. 188 - 191
DOI: 10.1126/science.7361115
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Articles

Science, Vol 208, Issue 4440, 188-191
Copyright © 1980 by American Association for the Advancement of Science

articles

Inhibition of cell division and growth by a redox series of cyanine dyes

S Zigman and P Gilman Jr

A series of cyanine dyes used in photography, with reduction potentials from -1.35 to -0.20 volts, were tested for their ability to inhibit mitosis and cell growth in fertilized sea urchin eggs. Low concentrations of dyes with reduction potentials more negative than -1.0 volt generally inhibited mitosis and growth, whereas those with more positive reduction potentials did not. The active dyes penetrated the cell, entered all subcellular compartments, were bound to numerous macromolecules, and inhibited synthesis of macromolecules. Thus mitosis and growth may be retarded with substances that can alter electrochemical activity in cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro.
S. Bernal, T. Lampidis, I. Summerhayes, and L. Chen (1982)
Science 218, 1117-1119
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