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Science 7 March 1980:
Vol. 207. no. 4435, pp. 1079 - 1080
DOI: 10.1126/science.7355272
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Articles

Science, Vol 207, Issue 4435, 1079-1080
Copyright © 1980 by American Association for the Advancement of Science

articles

Rat model for carcinogenesis in ureterosigmoidostomy

MM Crissey, GD Steele, and RF Gittes

A rat model is used to study the carcinogenesis that occurs when urine is surgically diverted into the fecal stream, as in ureterosigmoidostomy. Adenocarcinoma of the colon occurs adjacent to the urine inlet. It is completely prevented by proximal diversion of the feces, implying that fecal carcinogens are activated locally by the urine or the urothelium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Colon Cancer 15 Years After Ureterosigmoidostomy.
C. C.W. Chan, A. Tan, and H. Salman (2008)
J. Clin. Oncol. 26, 1755-1757
   Full Text »    PDF »
Tumorigenesis at a predetermined oral site after one intraperitoneal injection of N-nitroso-N-methylurea.
A Konstantinidis, J. Smulow, and C Sonnenschein (1982)
Science 216, 1235-1237
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)