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Science 15 February 1980:
Vol. 207. no. 4433, pp. 905 - 907
DOI: 10.1126/science.7188815
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Articles

Science, Vol 207, Issue 4433, 905-907
Copyright © 1980 by American Association for the Advancement of Science

articles

Multiple daily amphetamine administration: behavioral and neurochemical alterations

DS Segal, SB Weinberger, J Cahill, and SJ McCunney

In rats, multiple daily amphetamine injections (2.5 milligrams per kilogram of body weight, injected subcutaneously every 4 hours for 5 days) resulted in a progressive augmentation in response, characterized by a more rapid onset and an increased magnitude of stereotypy. By contrast, offset times of both the stereotypy and the poststereotypy hyperactivity periods were markedly shortened. When the animals were retested with the same dose of amphetamine 8 days after the long-term treatment was discontinued, the time of offset of the stereotypy and hyperactivity phases had recovered to values found with short-term amphetamine treatment, whereas the more rapid onset of stereotypy persisted. Brain monoamine and amphetamine concentrations and tyrosine hydroxylase activity were determined in comparably treated rats at times corresponding to the behavioral observations. The behavioral data indicate that enhanced responsiveness to amphetamine following its repeated administration may contribute to the development of amphetamine psychosis.


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