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Science 22 February 1980:
Vol. 207. no. 4433, pp. 904 - 907
DOI: 10.1126/science.207.4433.904
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Articles

Multiple Daily Amphetamine Administration: Behavioral and Neurochemical Alterations

DAVID S. SEGAL 1, SUSAN B. WEINBERGER 1, JEROME CAHILL 1, and STANLEY J. MCCUNNEY 1

1 Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla 92093

In rats, multiple daily amphetamine injections (2.5 milligrams per kilogram of body weight, injected subcutaneously every 4 hours for 5 days) resulted in a progressive augmentation in response, characterized by a more rapid onset and an increased magnitude of stereotypy. By contrast, offset times of both the stereotypy and the poststereotypy hyperactivity periods were markedly shortened. When the animals were retested with the same dose of amphetamine 8 days after the long-term treatment was discontinued, the time of offset of the stereotypy and hyperactivity phases had recovered to values found with short-term amphetamine treatment, whereas the more rapid onset of stereotypy persisted. Brain monoamine and amphetamine concentrations and tyrosine hydroxylase activity were determined in comparably treated rats at times corresponding to the behavioral observations. The behavioral data indicate that enhanced responsiveness to amphetamine following its repeated administration may contribute to the development of amphetamine psychosis.

Submitted on October 4, 1979


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Repeated Binge Exposures to Amphetamine and Methamphetamine: Behavioral and Neurochemical Characterization.
D. S. Segal and R. Kuczenski (1997)
J. Pharmacol. Exp. Ther. 282, 561-573
   Abstract »    Full Text »
An Escalating Dose "Binge" Model of Amphetamine Psychosis: Behavioral and Neurochemical Characteristics.
D. S. Segal and R. Kuczenski (1997)
J. Neurosci. 17, 2551-2566
   Abstract »    Full Text »    PDF »
Amphetamine and Dopamine-Induced Immediate Early Gene Expression in Striatal Neurons Depends on Postsynaptic NMDA Receptors and Calcium.
C. Konradi, J.-C. Leveque, and S. E. Hyman (1996)
J. Neurosci. 16, 4231-4239
   Abstract »    Full Text »    PDF »


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