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Science 15 February 1980:
Vol. 207. no. 4432, pp. 791 - 792
DOI: 10.1126/science.7352292
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Articles

Science, Vol 207, Issue 4432, 791-792
Copyright © 1980 by American Association for the Advancement of Science

articles

Bronchodilatation: noncholinergic, nonadrenergic mediation demonstrated in vivo in the cat

CG Irvin, R Boileau, J Tremblay, RR Martin, and PT Macklem

The composite vagus nerve was stimulated during intravenous infusion of 5-hydroxytryptamine in cats subjected to pharmacologic autonomic blockade with atropine, propranolol, and phentolamine. Bronchial caliber, as assessed by changes in pulmonary resistance, demonstrated a marked dilatation, and dilatation could still be demonstrated after preliminary treatment with reserpine. By stimulating the component branches of the vagus nerve, it was determined that the parasympathetic branch is responsible for this phenomenon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways.
Y Matsuzaki, Y Hamasaki, and S. Said (1980)
Science 210, 1252-1253
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