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Science 15 February 1980:
Vol. 207. no. 4432, pp. 775 - 777
DOI: 10.1126/science.6766222
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Articles
Science, Vol 207, Issue 4432, 775-777
Copyright © 1980 by American Association for the Advancement of Science
The heart is a target organ for androgen
HC McGill Jr,
VC Anselmo,
JM Buchanan,
and
PJ Sheridan
Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known, the presence of this receptor suggests that sex steroid hormones may affect myocardial function directly and may explain some of the peculiar differences in heart disease between men and women.
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