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Science 15 February 1980:
Vol. 207. no. 4432, pp. 768 - 769
DOI: 10.1126/science.7352285
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Articles

Science, Vol 207, Issue 4432, 768-769
Copyright © 1980 by American Association for the Advancement of Science

articles

Abnormality of the X chromosome in human 46,XY female siblings with dysgenetic ovaries

R Bernstein, GC Koo, and SS Wachtel

An abnormal extra band was found on the short arm of the X chromosome in a 46,XY female and in her 46,XY female fetal sibling. Despite presence of the intact Y chromosome, there was no evidence of testicular differentiation in either subject. Production of H-Y antigen was suppressed in both subjects. The data suggest that development of the mammalian testis requires a normal function of the X chromosome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Familial Sex Reversal: A Review.
K. Sarafoglou and H. Ostrer (2000)
J. Clin. Endocrinol. Metab. 85, 483-493
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Regulation of Sexual Dimorphism in Mammals.
C. M. HAQQ and P. K. DONAHOE (1998)
Physiol Rev 78, 1-33
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The Y Chromosome and Primary Sexual Differentiation.
R. Bernstein (1981)
JAMA 245, 1953-1956
   Abstract »    PDF »
Mammalian gonadal determination and gametogenesis.
J. Gordon and F. Ruddle (1981)
Science 211, 1265-1271
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Mechanisms of gonadal differentiation.
F. Haseltine and S Ohno (1981)
Science 211, 1272-1278
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