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Science 1 February 1980:
Vol. 207. no. 4430, pp. 530 - 532
DOI: 10.1126/science.7352262
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Articles

Science, Vol 207, Issue 4430, 530-532
Copyright © 1980 by American Association for the Advancement of Science

articles

Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis

V Schusdziarra, E Zyznar, D Rouiller, G Boden, JC Brown, A Arimura, and RH Unger

Free (approximately 1600 daltons) somatostatin-like immunoreactivity was identified in arterial plasma of dogs that had received a test meal. Neutralization of circulating somatostatin while the dogs were consuming a fatty meal increased the plasma concentrations of triglycerides, gastrin, pancreatic polypeptide, and insulin after the meal. It is concluded that, in the dog, somatostatin is a true hormone that regulates the movement of nutrients from the gut to the internal environment.


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Somatostatin (Somatostatinlike) Immunoreactive Cells in the Human Inner Ear.
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Prevention of Postprandial Hypotension with Somatostatin.
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