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Science 18 January 1980:
Vol. 207. no. 4428, pp. 331 - 333
DOI: 10.1126/science.7350667
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Articles

Science, Vol 207, Issue 4428, 331-333
Copyright © 1980 by American Association for the Advancement of Science

articles

Schizophrenia: elevated cerebrospinal fluid norepinephrine

CR Lake, DE Sternberg, DP van Kammen, JC Ballenger, MG Ziegler, RM Post, IJ Kopin, and WE Bunney

Concentrations of norepinephrine in cerebrospinal fluid are higher in schizophrenic patients, particularly in those with paranoid features, than in normal volunteer subjects of the same age. This observation supports recent reports of elevated concentrations of norepinephrine in specific brain areas adjacent to the cerebral ventricles of paranoid schizophrenic patients. Overflow of the amine from periventricular regions into the cerebrospinal fluid may reflect abnormally high release or diminished enzymatic destruction of norepinephrine in patients with schizophrenia.


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