Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 January 1980:
Vol. 207. no. 4428, pp. 321 - 323
DOI: 10.1126/science.7350665
Prev | Table of Contents | Next

Articles

Science, Vol 207, Issue 4428, 321-323
Copyright © 1980 by American Association for the Advancement of Science

articles

Origin of chi46,XX/46,XY chimerism in a human true hermaphrodite

G Dewald, MW Haymond, JL Spurbeck, and SB Moore

Using chromosome heteromorphisms and blood cell types as genetic markers, we demonstrated chimerism in a chi46,XX/46,XY true hermaphrodite. The pattern of inheritance of the chromosome heteromorphisms indicates that this individual was probably conceived by the fertilization, by two different spermatozoa, of an ovum and the second meiotic division polar body derived from the ovum and subsequent fusion of the two zygotes. This conclusion is based on the identification of the same maternal chromosomes 13, 16, and 21 in both the 46,XX and 46,XY cells of the patient. In the two cell lines of the chimera, chromosomal markers showed different paternal No. 9 chromosomes and sex chromosomes, as well as the same paternal chromosome 22.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Postzygotic diploidization of triploids as a source of unusual cases of mosaicism, chimerism and twinning.
M.D. Golubovsky (2003)
Hum. Reprod. 18, 236-242
   Abstract »    Full Text »    PDF »
Multiple metachromatic leucodystrophy alleles in an unaffected subject: a case of dispermic chimaerism.
M B Coulter-Mackie, J Rip, M J Beis, P Ferreira, and M D Ludman (2001)
J. Med. Genet. 38, 15e-15
   Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)