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Science 18 January 1980:
Vol. 207. no. 4428, pp. 309 - 311
DOI: 10.1126/science.7350660
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Articles

Science, Vol 207, Issue 4428, 309-311
Copyright © 1980 by American Association for the Advancement of Science

articles

Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection

MR Mauk, RC Gamble, and JD Baldeschwieler

When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicle with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles.
R. Proffitt, L. Williams, C. Presant, G. Tin, J. Uliana, R. Gamble, and J. Baldeschwieler (1983)
Science 220, 502-505
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