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Science 4 January 1980:
Vol. 207. no. 4426, pp. 80 - 82
DOI: 10.1126/science.6153130
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Articles

Science, Vol 207, Issue 4426, 80-82
Copyright © 1980 by American Association for the Advancement of Science

articles

Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein

TC Theoharides, W Sieghart, P Greengard, and WW Douglas

Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.


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