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Science 4 January 1980:
Vol. 207. no. 4426, pp. 78 - 80
DOI: 10.1126/science.7350643
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Articles

Science, Vol 207, Issue 4426, 78-80
Copyright © 1980 by American Association for the Advancement of Science

articles

Placental beta-endorphin-like peptides

JC Houck, C Kimball, C Chang, NW Pedigo, and HI Yamamura

Acid extract of human placental tissue contain, by both radioimmunoassay and radioreceptor assay, beta-endrophin-like material. Half of this material will not go through a 5000-dalton filter and on Sephadex G-200 has a molecular size between 25,00 and 50,000 daltons. Of the material going through a 5000-dalton ultrafilter, 80 percent is excluded on Sephadex G-25 and held back, very slightly, on Bio-Rad P6, indicating a molecular size of approximately 4500 to 4800 daltons. Thus, placenta appears to have macromolecular precursors from which a beta-endorphin-like material is released, with a size approximately 12 amino acids longer than half of the pituitary hormone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endorphin-mediated increases in pain threshold during pregnancy.
A. Gintzler (1980)
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Mood and behavioral effects of physostigmine on humans are accompanied by elevations in plasma beta-endorphin and cortisol.
S. Risch, R. Cohen, D. Janowsky, N. Kalin, and D. Murphy (1980)
Science 209, 1545-1546
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Dexamethasone fails to suppress beta-endorphin plasma concentrations in humans and rhesus monkeys.
N. Kalin, S. Risch, R. Cohen, T Insel, and D. Murphy (1980)
Science 209, 827-828
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High-molecular-weight immunoreactive beta-endorphin in extracts of human placenta is a fragment of immunoglobulin G.
J. Julliard, T Shibasaki, N Ling, and R Guillemin (1980)
Science 208, 183-185
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