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Science 21 December 1979:
Vol. 206. no. 4425, pp. 1421 - 1423
DOI: 10.1126/science.388619
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Articles

Science, Vol 206, Issue 4425, 1421-1423
Copyright © 1979 by American Association for the Advancement of Science

articles

Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes

AA Like, AA Rossini, DL Guberski, MC Appel, and RM Williams

Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Murine Antithymocyte Globulin Therapy Alters Disease Progression in NOD Mice by a Time-Dependent Induction of Immunoregulation.
G. Simon, M. Parker, V. Ramiya, C. Wasserfall, Y. Huang, D. Bresson, R. F. Schwartz, M. Campbell-Thompson, L. Tenace, T. Brusko, et al. (2008)
Diabetes 57, 405-414
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Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes.
B. Keymeulen, E. Vandemeulebroucke, A. G. Ziegler, C. Mathieu, L. Kaufman, G. Hale, F. Gorus, M. Goldman, M. Walter, S. Candon, et al. (2005)
N. Engl. J. Med. 352, 2598-2608
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Cellular and Molecular Mechanism for Kilham Rat Virus-Induced Autoimmune Diabetes in DR-BB Rats.
Y.-H. Chung, H. S. Jun, M. Son, M. Bao, H. Y. Bae, Y. Kang, and J.-W. Yoon (2000)
J. Immunol. 165, 2866-2876
   Abstract »    Full Text »    PDF »
Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth.
A. Posselt, C. Barker, A. Friedman, and A Naji (1992)
Science 256, 1321-1324
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Passive transfer of diabetes in the BB/W rat.
S Koevary, A Rossini, W Stoller, W Chick, and R. Williams (1983)
Science 220, 727-728
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Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.
A. Rossini, J. Mordes, A. Pelletier, and A. Like (1983)
Science 219, 975-977
   Abstract »    PDF »
Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat.
A. Like, E Kislauskis, R. Williams, and A. Rossini (1982)
Science 216, 644-646
   Abstract »    PDF »
Spontaneous diabetes in rats: destruction of islets is prevented by immunological tolerance.
A Naji, W. Silvers, D Bellgrau, and C. Barker (1981)
Science 213, 1390-1392
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