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Science 14 December 1979:
Vol. 206. no. 4424, pp. 1317 - 1319
DOI: 10.1126/science.229552
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Articles

Science, Vol 206, Issue 4424, 1317-1319
Copyright © 1979 by American Association for the Advancement of Science

articles

Killing of fibroblasts by dexamethasone or dibutyryl adenosine 3',5'-monophosphate is not a valid test for cystic fibrosis

JB Kurz, JP Perkins, and M Buchwald

Assays based on the counting of total cells and of colony-forming cells were used to demonstrate that neither dexamethasone nor dibutyryl adenosine 3',5'-monophosphate (cyclic AMP) kills human fibroblasts under a variety of conditions. These results contradict those of previous studies showing that dexamethasone and dibutyryl cyclic AMP kill a higher percentage of fibroblasts from normal humans than from individuals with cystic fibrosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential killing of normal and cystic fibrosis fibroblasts by dexamethasone.
J. Breslow and J Epstein (1980)
Science 207, 1007-1008
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