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Science 14 December 1979:
Vol. 206. no. 4424, pp. 1313 - 1314
DOI: 10.1126/science.316187
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Articles

Science, Vol 206, Issue 4424, 1313-1314
Copyright © 1979 by American Association for the Advancement of Science

articles

Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung

A Janoff, H Carp, DK Lee, and RT Drew

Brief inhalation exposure of rats to three or six puffs of cigarette smoke significantly decreases elastase inhibitory capacity per milligram of alpha 1-antitrypsin in lung lavage fluid. This effect is not observed in ozone-tolerant rats and can be reversed by treating the lung lavage fluid from smoke-exposed rats with reducing agents. Samples of human serum obtained immediately after smoking also show decreased elastase inhibitory capacity per milligram of alpha 1-antitrypsin. Again, elastase inhibitory capacity can be restored by treatment with a reducing agent. Cigarette smoking may cause emphysema by inactivating alpha 1-antitrypsin through oxidation.


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