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Science 7 December 1979:
Vol. 206. no. 4423, pp. 1190 - 1191
DOI: 10.1126/science.505005
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Articles

Science, Vol 206, Issue 4423, 1190-1191
Copyright © 1979 by American Association for the Advancement of Science

articles

A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin

M Brownlee and A Cerami

A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.


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