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Science 30 November 1979:
Vol. 206. no. 4422, pp. 1097 - 1099
DOI: 10.1126/science.573923
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Articles

Science, Vol 206, Issue 4422, 1097-1099
Copyright © 1979 by American Association for the Advancement of Science

articles

Prenatal stress reduces fertility and fecundity in female offspring

LR Herrenkohl

Female rats subjected to prenatal stress later experienced fewer conceptions, more spontaneous abortions and vaginal hemorrhaging, longer pregnancies, and fewer viable young than nonstressed rats. The offspring of the prenatally stressed rats were lighter in weight and less likely to survive the neonatal period. Prenatal stress may influence the balance of adrenal and gonadal hormones during a critical stage of fetal hypothalamic differentiation, thereby producing a variety of reproductive dysfunctions in adulthood.


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